Abstract: To further promote the high-quality development in the Yangtze River Economic Belt, it is necessary to solve the three major contradictions between the ecological environment and the industrial structure, between the development of regional coordination and integration and the market segmentation, and between the development of internal circulation and the development of external circulation. Strengthening regional coordination and integration is the key path and main way to solve these contradictions and achieve high-quality development of the Yangtze River Economic Belt. The result of the analysis of the regional coordination and integration in the Yangtze River Economic Belt shows that on the one hand, there are the market segmentation and the protection of regional governments, on the other hand, the real situation is the uneven development in various regions, which hinders the ability of provincial and municipal economies to obtain the economies of scale and scope, thus becoming the main reason for hindering and restricting the coordination and integration of various regions in the Yangtze River Economic Belt. In order to promote regional coordination and integration and achieve regional collaborative and integrated development, we need not only to vigorously promote the integrated cooperation between local governments, but also we need to form a unified large market with free flow of commodity factor resources and fair competition. On the basis of “overall strategy, planning with one blueprint, environmental protection with one standard, and one transportation network”, we should promote the joint construction of the Yangtze River Science and Technology Innovation Corridor along the Yangtze River Economic Belt, promote the coordinated and integrated development of world-class advanced manufacturing clusters in the Yangtze River Economic Belt, and construct a new international and domestic dual circulation development pattern dominated by domestic demand.

Key words: Yangtze River Economic Belt, high-quality development, regional synergy and integration, regional unified market